abstract：:DNA profiles from degraded samples often suffer from information loss at the longer short tandem repeat (STR) loci. Sensitising the reactions, either by performing additional PCR cycles or increasing the capillary electrophoresis injection settings, carries the risk of over-amplifying or overloading the shorter fragme...

journal_title：International journal of legal medicine

authors： Westen AA,van der Gaag KJ,de Knijff P,Sijen T

更新日期：2013-07-01 00:00:00

abstract：:The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investig...

journal_title：International journal of legal medicine

authors： Palmiere C,Mussap M,Bardy D,Cibecchini F,Mangin P

更新日期：2013-07-01 00:00:00

abstract：:P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood-brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In thi...

journal_title：International journal of legal medicine

authors： Karlsson L,Green H,Zackrisson AL,Bengtsson F,Jakobsen Falk I,Carlsson B,Ahlner J,Kugelberg FC

更新日期：2013-05-01 00:00:00

abstract：:When a forensic DNA sample cannot be associated directly with a previously genotyped reference sample by standard short tandem repeat profiling, the investigation required for identifying perpetrators, victims, or missing persons can be both costly and time consuming. Here, we describe the outcome of a collaborative s...

journal_title：International journal of legal medicine

authors： Keating B,Bansal AT,Walsh S,Millman J,Newman J,Kidd K,Budowle B,Eisenberg A,Donfack J,Gasparini P,Budimlija Z,Henders AK,Chandrupatla H,Duffy DL,Gordon SD,Hysi P,Liu F,Medland SE,Rubin L,Martin NG,Spector TD,Kay

更新日期：2013-05-01 00:00:00

abstract：:We hypothesized that miRNAs present in vitreous humor could be a sort of "biological black box," storing information about physiological and environmental circumstances at death. As a proof of concept, we analyzed the vitreous humor miRNA signature to explore its forensic potential applications, such as determining th...

journal_title：International journal of legal medicine

authors： Odriozola A,Riancho JA,de la Vega R,Agudo G,García-Blanco A,de Cos E,Fernández F,Sañudo C,Zarrabeitia MT

更新日期：2013-05-01 00:00:00

abstract：:In cooperation with the Crime Investigation Agency (Landeskriminalamt) of North Rhine-Westphalia, we carried out a study of 150 cases of (suspected) neonaticide dating from 1993 to 2007 from all over Germany. The autopsy reports and additional expert opinions (if performed) were evaluated for a minimum of 78 variables...

journal_title：International journal of legal medicine

authors： Schulte B,Rothschild MA,Vennemann M,Banaschak S

更新日期：2013-05-01 00:00:00

abstract：:In order to establish a reliable age indicator in the period when all other epiphyseal age indicators have already been inactivated, medial clavicle as the bone with the longest period of growth became the object of various investigations. However, the lack of population-specific method often made it unreliable in som...

journal_title：International journal of legal medicine

authors： Milenkovic P,Djukic K,Djonic D,Milovanovic P,Djuric M

更新日期：2013-05-01 00:00:00

abstract：:Due to the increasing significance of forensic age estimations in the age of globalisation, novel radiographic criteria besides clavicles and hand bones may provide additional certainty for forensic age expertises. The present study analyses the suitability of the iliac crest apophysis by means of 643 pelvic radiograp...

journal_title：International journal of legal medicine

authors： Wittschieber D,Vieth V,Domnick C,Pfeiffer H,Schmeling A

更新日期：2013-03-01 00:00:00

abstract：:The identification of species of the forensically important genus Sarcophaga is very difficult and requires strong taxonomic expertise. In this study, we sequenced the mitochondrial cytochrome c oxidase subunit I (COI) gene of 126 specimens of 56 W European Sarcophaga species and added GenBank data to our database to ...

journal_title：International journal of legal medicine

authors： Jordaens K,Sonet G,Richet R,Dupont E,Braet Y,Desmyter S

更新日期：2013-03-01 00:00:00

abstract：:Short tandem repeat (STR) polymorphisms have been extensively used in forensic genetics analysis. Knowledge about the locus-specific mutation rates of STRs improves forensic probability calculations and interpretations of diversity data. To incorporate single-locus diversity information into autosomal STR mutation rat...

journal_title：International journal of legal medicine

authors： Mardini AC,Rodenbusch R,Schumacher S,Chula FG,Michelon CT,Gastaldo AZ,Maciel LP,de Matos Almeida SE,da Silva CM

更新日期：2013-01-01 00:00:00

abstract：:The goal of the present study is to examine cross-sectional information on the growth of the humerus based on the analysis of four measurements, namely, diaphyseal length, transversal diameter of the proximal (metaphyseal) end of the shaft, epicondylar breadth and vertical diameter of the head. This analysis was perfo...

journal_title：International journal of legal medicine

authors： Rissech C,López-Costas O,Turbón D

更新日期：2013-01-01 00:00:00

abstract：:Necrophagous blow fly larvae can provide accurate estimates of the minimum postmortem interval in death investigations. During larval development, predictable morphological changes occur and measurements of weight, length, and width are compared to species-specific growth curves for reliable age estimates. However, ag...

journal_title：International journal of legal medicine

authors： Boehme P,Spahn P,Amendt J,Zehner R

更新日期：2013-01-01 00:00:00

abstract：:The development rate of immature Calliphora vicina reared on decomposed liver was significantly slower, by as much as 30 h (55.4 % of total development time) for mid-sized larvae, and 71 h (35.0 %) and 58 h (14.6 %) if using times to the onset of pupariation and eclosion, respectively, than those of immatures that dev...

journal_title：International journal of legal medicine

authors： Richards CS,Rowlinson CC,Cuttiford L,Grimsley R,Hall MJ

更新日期：2013-01-01 00:00:00

abstract：:The smoking cessation agent varenicline acts as a partial agonist on α(4)β(2) nicotinic acetylcholine receptors. Although debated, several reports have linked varenicline therapy to an increased risk of suicidal thoughts and/or suicide. In addition, several non-fatal overdose cases have been reported. In this report, ...

journal_title：International journal of legal medicine

authors： Stove CP,De Letter EA,Piette MH,Lambert WE

更新日期：2013-01-01 00:00:00

abstract：:When blood reaches an extracorporeal surface, a drying process is initiated. Properties of this drying process may be crucial for the correct assessment of case-specific time lapses, however, there is a lack of systematic studies concerning the drying times of blood. We present a study on drying properties of small bl...

journal_title：International journal of legal medicine

authors： Ramsthaler F,Schmidt P,Bux R,Potente S,Kaiser C,Kettner M

更新日期：2012-09-01 00:00:00

abstract：:Recently, Verzeletti et al. (Am J Forensic Med Pathol 31:27-33, 2010) developed a new components method for the estimation of age-at-death from the sternal end of the fourth rib. This approach consists of the assignment of numerical scores for several age-related morphological characteristics, which are then inserted ...

journal_title：International journal of legal medicine

authors： Macaluso PJ Jr,Lucena J

更新日期：2012-09-01 00:00:00

abstract：:A study was performed on the detection, separation and quantification of isomers from the new designer drugs named fluoroamphetamines (FAs) in forensic cases in eastern Denmark. The drugs were detected in whole blood extracts by ultraperformance liquid chromatography with time of flight mass spectrometer (UPLC-TOF-MS)...

journal_title：International journal of legal medicine

authors： Johansen SS,Hansen TM

更新日期：2012-07-01 00:00:00

abstract：:The main criteria used in dental age estimation in living young individuals are mineralisation and eruption of the third molars. In order to further diversify the spectrum of characteristics after completion of third molar development, tests were undertaken to determine whether the characteristics studied by Gustafson...

journal_title：International journal of legal medicine

authors： Olze A,Hertel J,Schulz R,Wierer T,Schmeling A

更新日期：2012-07-01 00:00:00

abstract：:Insertion-deletion (INDEL) markers are very frequent in the human genome and present several advantages for population and forensic studies, such as low mutation rates, easy interpretation, small amplicons, easy genotyping, and the possibility of using multiplex PCR. The great adaptability of INDELs for amplification ...

journal_title：International journal of legal medicine

authors： da Costa Francez PA,Rodrigues EM,de Velasco AM,dos Santos SE

更新日期：2012-07-01 00:00:00

abstract：:We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 %. The diversity values ...

journal_title：International journal of legal medicine

authors： Samejima M,Nakamura Y,Nambiar P,Minaguchi K

更新日期：2012-07-01 00:00:00

abstract：:The authors report on a young boy who was bitten into his face by an unknown animal while being asleep in a tent. Given the bite marks and the location of the scene, members of the mustelidae and canidae families were the first "suspects." Deoxyribunucleic acid (DNA) recovered from the tent's wall was analyzed with re...

journal_title：International journal of legal medicine

authors： Naue J,Lutz-Bonengel S,Pietsch K,Sänger T,Schlauderer N,Schmidt U

更新日期：2012-05-01 00:00:00

abstract：:We developed two multiplex systems for the coamplification of X-chromosomal short tandem repeats (STRs). X-Multiplex 1 consisted of DXS6807, DXS6800, DXS7424, DXS101, GATA172D05 and HPRTB and X-Multiplex 2 consisted of DXS8378, DXS9898, DXS6801, DXS6809, DXS6789, DXS7133, DXS8377 and DXS7423. In addition, we present a...

journal_title：International journal of legal medicine

authors： Penna LS,Silva FG,Salim PH,Ewald G,Jobim M,Magalhães JA,Jobim LF

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:We investigated the incidence and distribution of post-mortem gas detected with multidetector computed tomography (MDCT) to identify factors that could distinguish artifactual gas from cardiac air embolism. MATERIAL AND METHODS:MDCT data of 119 cadavers were retrospectively examined. Gas was semiquantitatively...

journal_title：International journal of legal medicine

authors： Egger C,Bize P,Vaucher P,Mosimann P,Schneider B,Dominguez A,Meuli R,Mangin P,Grabherr S

更新日期：2012-01-01 00:00:00

abstract：:During forensic investigations, it is often important to be able to distinguish between impact spatter patterns (blood from gunshots, explosives, blunt force trauma and/or machinery accidents) and bloodstain patterns generated by expiration (blood from the mouth, nose or lungs). These patterns can be difficult to dist...

journal_title：International journal of legal medicine

authors： Donaldson AE,Walker NK,Lamont IL,Cordiner SJ,Taylor MC

更新日期：2011-11-01 00:00:00

abstract：:In certain circumstances, tumour tissue specimens are the only DNA resource available for forensic DNA analysis. However, cancer tissues can show microsatellite instability and loss of heterozygosity which, if concerning the short tandem repeats (STRs) used in the forensic field, can cause misinterpretation of the res...

journal_title：International journal of legal medicine

authors： Ananian V,Tozzo P,Ponzano E,Nitti D,Rodriguez D,Caenazzo L

更新日期：2011-05-01 00:00:00

abstract：:Due to the requirement to minimise exposure to radiation, it is desirable to develop non-ionising imaging procedures for the analysis of skeletal maturation for forensic age diagnostics in living individuals. The present pilot study analyses the applicability of ultrasound examinations for the evaluation of apophyseal...

journal_title：International journal of legal medicine

authors： Schmidt S,Schmeling A,Zwiesigk P,Pfeiffer H,Schulz R

更新日期：2011-03-01 00:00:00

abstract：:The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known ...

journal_title：International journal of legal medicine

authors： Muzzio M,Ramallo V,Motti JM,Santos MR,López Camelo JS,Bailliet G

更新日期：2011-01-01 00:00:00

abstract：:Thyroid hormones are sometimes used for purposes for which they are not approved. Reasons for off-label use can be overweight, prevailing depressive mood, or various somatic symptoms. Information about the intake of thyroid hormones in order to lose weight can be easily obtained from inappropriate/nonmedical websites....

journal_title：International journal of legal medicine

authors： Hartung B,Schott M,Daldrup T,Ritz-Timme S

更新日期：2010-11-01 00:00:00

abstract：:We present a single case report illustrating the diagnostic role of multi-slice computed tomography (MSCT) in the investigation of suspicious child death where mechanical asphyxia is suspected. The case illustrates how radiological findings that may not be observable on conventional plain X-ray were identified by post...

journal_title：International journal of legal medicine

authors： Rutty GN,Jeffery AJ,Raj V,Morgan B

更新日期：2010-11-01 00:00:00

abstract：:The accuracy of forensic age estimation based on the chronology of second (M2) and third molar (M3) development was investigated using 2,087 orthopantomograms of Korean men and women aged between 3 and 23 years. The developmental stages of M2s and M3s in these subjects were classified using the criteria of Demirjian. ...

journal_title：International journal of legal medicine

authors： Lee SS,Byun YS,Park MJ,Choi JH,Yoon CL,Shin KJ

更新日期：2010-11-01 00:00:00

abstract：:Gene expression analyses based on messenger RNA (mRNA) profiling require accurate data normalisation. When using endogenous reference genes, these have to be validated carefully. Therefore, we examined the transcript stability of 10 potential reference genes using quantitative real-time polymerase chain reaction: beta...

journal_title：International journal of legal medicine

authors： Koppelkamm A,Vennemann B,Fracasso T,Lutz-Bonengel S,Schmidt U,Heinrich M

更新日期：2010-09-01 00:00:00

abstract：:Linking biological samples found at a crime scene with the actual crime event represents the most important aspect of forensic investigation, together with the identification of the sample donor. While DNA profiling is well established for donor identification, no reliable methods exist for timing forensic samples. He...

journal_title：International journal of legal medicine

authors： Ackermann K,Ballantyne KN,Kayser M

更新日期：2010-09-01 00:00:00

abstract：:Human fingertip microflora is transferred to touched objects and may provide forensically relevant information on individual hosts, such as on geographic origins, if endogenous microbial skin species/strains would be retrievable from physical fingerprints and would carry geographically restricted DNA diversity. We tes...

journal_title：International journal of legal medicine

authors： Tims S,van Wamel W,Endtz HP,van Belkum A,Kayser M

更新日期：2010-09-01 00:00:00

abstract：:The craniofacial superimposition technique is still an important way of identifying skulls when there is no reference sample for a forensic DNA analysis, when DNA typing from remaining tissue samples has failed, or when antemortem dental records are not available. Through the widespread use of digital photography, the...

journal_title：International journal of legal medicine

authors： Birngruber CG,Kreutz K,Ramsthaler F,Krähahn J,Verhoff MA

更新日期：2010-09-01 00:00:00

abstract：:The aim of this paper is twofold: first, to evaluate an Indian sample by Cameriere's European formula; and second, if this formula turns out to be unsuitable, to study a specific formula for Indian children. Orthopantomographs taken from 480 Indian children (227 girls and 253 boys) aged between 3 and 15 years were ana...

journal_title：International journal of legal medicine

authors： Rai B,Kaur J,Cingolani M,Ferrante L,Cameriere R

更新日期：2010-05-01 00:00:00

abstract：:The question of whether an individual has reached the age of 18 is of crucial importance in forensic age estimation practice. In some countries, the age threshold of 21 years is relevant as well. A completed mineralization of third molars is not a sufficient criterion for a diagnosis of a minimum age of 18 years with ...

journal_title：International journal of legal medicine

authors： Olze A,Solheim T,Schulz R,Kupfer M,Schmeling A

更新日期：2010-05-01 00:00:00

abstract：:The scope of this study was to evaluate the incidence and the eventual consequences of amniotic fluid aspiration (AFA) in cases of sudden infant death. Cases of sudden infant death syndrome (SIDS; n = 113: 39 females, 74 males; mean age 4.6 months) were compared to a control group of 39 cases of explained death (14 fe...

journal_title：International journal of legal medicine

authors： Fracasso T,Karger B,Vennemann M,Bajanowski T,Golla-Schindler UM,Pfeiffer H

更新日期：2010-03-01 00:00:00

abstract：:We investigated control and coding region polymorphisms in mitochondrial DNA (mtDNA) in 100 unrelated individuals from a Japanese population and determined the basal phylogenetic haplogroup lineages in all samples under updated information. Many of the basal phylogenetic haplogroup lineages assigned on East Asian mtDN...

journal_title：International journal of legal medicine

authors： Nohira C,Maruyama S,Minaguchi K

更新日期：2010-01-01 00:00:00

abstract：:The use of tracker dogs is the main method of finding hidden bodies, and in their search the dogs use typical scent patterns. "Electronic noses" can also be used to find and compare such patterns. Highly sensitive scent detectors have been successfully applied, e.g. in the examination of foodstuffs, in environmental t...

journal_title：International journal of legal medicine

authors： Hädrich C,Ortmann C,Reisch R,Liebing G,Ahlers H,Mall G

更新日期：2010-01-01 00:00:00

abstract：:We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb dista...

journal_title：International journal of legal medicine

authors： Edelmann J,Hering S,Augustin C,Kalis S,Szibor R

更新日期：2010-01-01 00:00:00